Sustained Immunological Responses to Highly Active Antiretroviral Therapy at 36 Months in a Ghanaian HIV Cohort
Identifieur interne : 000A44 ( Main/Exploration ); précédent : 000A43; suivant : 000A45Sustained Immunological Responses to Highly Active Antiretroviral Therapy at 36 Months in a Ghanaian HIV Cohort
Auteurs : Paul Collini [Ghana, Royaume-Uni] ; Uli Schwab [Ghana] ; Stephen Sarfo [Ghana] ; Joseph Obeng-Baah [Ghana] ; Betty Norman [Ghana] ; David Chadwick ; David Bibby [Royaume-Uni] ; George Bedu-Addo [Ghana]Source :
- Clinical Infectious Diseases [ 1058-4838 ] ; 2009-04-01.
Descripteurs français
- KwdFr :
- MESH :
- traitement médicamenteux : Infections à VIH.
- usage thérapeutique : Agents antiVIH.
- Adolescent, Adulte, Adulte d'âge moyen, Femelle, Ghana, Humains, Jeune adulte, Mâle, Numération des lymphocytes CD4, Résultat thérapeutique, Thérapie antirétrovirale hautement active, Études longitudinales.
- Wicri :
- geographic : Ghana.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Anti-HIV Agents.
- geographic : Ghana.
- drug therapy : HIV Infections.
- Adolescent, Adult, Antiretroviral Therapy, Highly Active, CD4 Lymphocyte Count, Female, Humans, Longitudinal Studies, Male, Middle Aged, Treatment Outcome, Young Adult.
Abstract
Two hundred thirty-seven Ghanaian human immunodeficiency virus–infected patients who were starting antiretroviral therapy underwent clinical and immunological monitoring for 3 years. Seventy-eight percent of patients had disease classified as World Health Organization stage III or IV. The mean increase in the CD4 cell count was 395 cells/mm>3, 13% of patients experienced immunological failure, and 8% of patients switched treatment to a second-line regimen. However, two-thirds of patients who experienced immunological failure did not switch treatment, and 31% of all patients were lost to follow-up.
Url:
DOI: 10.1086/597353
Affiliations:
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xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Agents antiVIH (usage thérapeutique)</term><term>Femelle</term><term>Ghana</term><term>Humains</term><term>Infections à VIH (traitement médicamenteux)</term><term>Jeune adulte</term><term>Mâle</term><term>Numération des lymphocytes CD4</term><term>Résultat thérapeutique</term><term>Thérapie antirétrovirale hautement active</term><term>Études longitudinales</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anti-HIV Agents</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Ghana</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>HIV Infections</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à VIH</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Agents antiVIH</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Antiretroviral Therapy, Highly Active</term><term>CD4 Lymphocyte Count</term><term>Female</term><term>Humans</term><term>Longitudinal Studies</term><term>Male</term><term>Middle Aged</term><term>Treatment Outcome</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Femelle</term><term>Ghana</term><term>Humains</term><term>Jeune adulte</term><term>Mâle</term><term>Numération des lymphocytes CD4</term><term>Résultat thérapeutique</term><term>Thérapie antirétrovirale hautement active</term><term>Études longitudinales</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Ghana</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">Two hundred thirty-seven Ghanaian human immunodeficiency virus–infected patients who were starting antiretroviral therapy underwent clinical and immunological monitoring for 3 years. Seventy-eight percent of patients had disease classified as World Health Organization stage III or IV. The mean increase in the CD4 cell count was 395 cells/mm>3, 13% of patients experienced immunological failure, and 8% of patients switched treatment to a second-line regimen. However, two-thirds of patients who experienced immunological failure did not switch treatment, and 31% of all patients were lost to follow-up.</div></front></TEI><affiliations><list><country><li>Ghana</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement></list><tree><noCountry><name sortKey="Chadwick, David" sort="Chadwick, David" uniqKey="Chadwick D" first="David" last="Chadwick">David Chadwick</name></noCountry><country name="Ghana"><noRegion><name sortKey="Collini, Paul" sort="Collini, Paul" uniqKey="Collini P" first="Paul" last="Collini">Paul Collini</name></noRegion><name sortKey="Bedu Addo, George" sort="Bedu Addo, George" uniqKey="Bedu Addo G" first="George" last="Bedu-Addo">George Bedu-Addo</name><name sortKey="Bedu Addo, George" sort="Bedu Addo, George" uniqKey="Bedu Addo G" first="George" last="Bedu-Addo">George Bedu-Addo</name><name sortKey="Collini, Paul" sort="Collini, Paul" uniqKey="Collini P" first="Paul" last="Collini">Paul Collini</name><name sortKey="Norman, Betty" sort="Norman, Betty" uniqKey="Norman B" first="Betty" last="Norman">Betty Norman</name><name sortKey="Norman, Betty" sort="Norman, Betty" uniqKey="Norman B" first="Betty" last="Norman">Betty Norman</name><name sortKey="Obeng Baah, Joseph" sort="Obeng Baah, Joseph" uniqKey="Obeng Baah J" first="Joseph" last="Obeng-Baah">Joseph Obeng-Baah</name><name sortKey="Obeng Baah, Joseph" sort="Obeng Baah, Joseph" uniqKey="Obeng Baah J" first="Joseph" last="Obeng-Baah">Joseph Obeng-Baah</name><name sortKey="Sarfo, Stephen" sort="Sarfo, Stephen" uniqKey="Sarfo S" first="Stephen" last="Sarfo">Stephen Sarfo</name><name sortKey="Sarfo, Stephen" sort="Sarfo, Stephen" uniqKey="Sarfo S" first="Stephen" last="Sarfo">Stephen Sarfo</name><name sortKey="Schwab, Uli" sort="Schwab, Uli" uniqKey="Schwab U" first="Uli" last="Schwab">Uli Schwab</name><name sortKey="Schwab, Uli" sort="Schwab, Uli" uniqKey="Schwab U" first="Uli" last="Schwab">Uli Schwab</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Collini, Paul" sort="Collini, Paul" uniqKey="Collini P" first="Paul" last="Collini">Paul Collini</name></noRegion><name sortKey="Bibby, David" sort="Bibby, David" uniqKey="Bibby D" first="David" last="Bibby">David Bibby</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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